Title : Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A.

Pub. Date : 2002 May

PMID : 11982754






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Agonists that induce keratinocyte differentiation, specifically 12-0-tetradecanoyl-phorbol-13-acetate (TPA) plus ionomycin, TPA, and raised extracellular calcium, induced nuclear translocation of NFAT1 and calcineurin in keratinocytes that was inhibited by pretreatment with cyclosporin A or tacrolimus. Ionomycin nuclear factor of activated T cells 2 Homo sapiens