Pub. Date : 2002 May 1
PMID : 11980644
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment with retinoic acid (RA) or carnosol, two structurally unrelated compounds with anticancer properties, inhibited phorbol ester (PMA)-mediated induction of activator protein-1 (AP-1) activity and cyclooxygenase-2 (COX-2) expression in human mammary epithelial cells. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | Treatment with retinoic acid (RA) or carnosol, two structurally unrelated compounds with anticancer properties, inhibited phorbol ester (PMA)-mediated induction of activator protein-1 (AP-1) activity and cyclooxygenase-2 (COX-2) expression in human mammary epithelial cells. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | The induction of COX-2 transcription by PMA was mediated by increased binding of AP-1 to the cyclic AMP response element (CRE) of the COX-2 promoter. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | The induction of COX-2 transcription by PMA was mediated by increased binding of AP-1 to the cyclic AMP response element (CRE) of the COX-2 promoter. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 5 | Inhibition of the histone acetyltransferase activity of CREB- binding protein (CBP)/p300 blocked the induction of COX-2 by PMA. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 6 | Overexpressing c-Jun but not CBP/p300 reversed the suppressive effect of carnosol on PMA-mediated stimulation of COX-2 promoter activity. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |