Title : Nitecapone and selegiline as effective adjuncts to L-DOPA in reserpine-induced catatonia in mice.

Pub. Date : 2002 Jan-Feb

PMID : 11980384






2 Functional Relationships(s)
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1 It is concluded that COMT and MAO-B enzymes play an important role in the metabolism of dopamine and administration of a COMT or MAO-B inhibitor may prove to be a better adjunct to L-DOPA therapy than a dopamine receptor agonist in Parkinson"s disease. Levodopa catechol-O-methyltransferase Mus musculus
2 It is concluded that COMT and MAO-B enzymes play an important role in the metabolism of dopamine and administration of a COMT or MAO-B inhibitor may prove to be a better adjunct to L-DOPA therapy than a dopamine receptor agonist in Parkinson"s disease. Levodopa catechol-O-methyltransferase Mus musculus