Title : Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin.

Pub. Date : 2002 May 1

PMID : 11978772






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin. polyglutamine heat shock protein family B (small) member 1 Homo sapiens
2 In the present study, we identified heat shock protein 27 (HSP27) as a suppressor of poly(Q) mediated cell death, using a cellular model of HD. polyglutamine heat shock protein family B (small) member 1 Homo sapiens
3 In the present study, we identified heat shock protein 27 (HSP27) as a suppressor of poly(Q) mediated cell death, using a cellular model of HD. polyglutamine heat shock protein family B (small) member 1 Homo sapiens
4 We tested the hypotheses that HSP27 may reduce poly(Q)-mediated cell death either by binding cytochrome c and inhibiting the mitochondrial death pathway or by protecting against reactive oxygen species (ROS). polyglutamine heat shock protein family B (small) member 1 Homo sapiens