Pub. Date : 2002 May 1
PMID : 11978772
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin. | Reactive Oxygen Species | huntingtin | Homo sapiens |
| 2 | However, we observed that mutant huntingtin caused increased levels of ROS in neuronal and non-neuronal cells. | Reactive Oxygen Species | huntingtin | Homo sapiens |
| 3 | HSP27 decreased ROS in cells expressing mutant huntingtin, suggesting that this chaperone protects cells against oxidative stress. | Reactive Oxygen Species | huntingtin | Homo sapiens |