Title : Pinning down proline-directed phosphorylation signaling.

Pub. Date : 2002 Apr

PMID : 11978535






1 Functional Relationships(s)
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1 Recent identification of the novel prolyl isomerase Pin1 that specifically isomerizes only the phosphorylated Ser/Thr-Pro bonds in certain proteins led us to propose a new signaling mechanism, whereby prolyl isomerization catalytically induces conformational changes in proteins following phosphorylation to regulate protein function. Proline peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens