Title : Identification of a conserved motif required for mTOR signaling.

Pub. Date : 2002 Apr 16

PMID : 11967149






2 Functional Relationships(s)
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1 Furthermore, only overexpression of S6K1 with an intact TOS motif prevents 4E-BP1 phosphorylation by a common mTOR-regulated modulator of S6K1 and 4E-BP1. tos mechanistic target of rapamycin kinase Homo sapiens
2 CONCLUSIONS: S6K1 and 4E-BP1 contain a conserved five amino acid sequence (TOS motif) that is crucial for their regulation by the mTOR pathway. tos mechanistic target of rapamycin kinase Homo sapiens