Title : Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity.

Pub. Date : 2002 Apr 25

PMID : 11960490






2 Functional Relationships(s)
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1 Solution of the X-ray cocrystal structure of the ortho tetrazole analogue 29 bound to PTP1B revealed that the tetrazole moiety is well-accommodated in the active site and binds in a fashion similar to the ortho carboxylate analogue 2 reported previously. 1H-tetrazole protein tyrosine phosphatase non-receptor type 1 Homo sapiens
2 Solution of the X-ray cocrystal structure of the ortho tetrazole analogue 29 bound to PTP1B revealed that the tetrazole moiety is well-accommodated in the active site and binds in a fashion similar to the ortho carboxylate analogue 2 reported previously. 1H-tetrazole protein tyrosine phosphatase non-receptor type 1 Homo sapiens