Title : Cholinergic toxic syndrome by the anticancer drug irinotecan: acetylcholinesterase does not play a major role.

Pub. Date : 2002 Apr

PMID : 11956509






1 Functional Relationships(s)
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1 In vitro, the activity of acetylcholinesterase was inhibited by 100-micromol/L irinotecan (-24.8%) and markedly reduced by 1-micromol/L physostigmine (-86.7%), whereas neither SN-38 nor camptothecin had an effect. Physostigmine acetylcholinesterase (Cartwright blood group) Homo sapiens