Title : Interleukin-1beta-induced substance P release from rat cultured primary afferent neurons driven by two phospholipase A2 enzymes: secretory type IIA and cytosolic type IV.

Pub. Date : 2002 Mar

PMID : 11953449






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In the present study, we examined the involvement of two types of phospholipase A2 (PLA2) enzymes, which lie upstream of COX in the prostanoid-generating pathway, in the IL-1beta-induced release of SP from DRG cells. Prostaglandins phospholipase A2 group IB Rattus norvegicus
2 In the present study, we examined the involvement of two types of phospholipase A2 (PLA2) enzymes, which lie upstream of COX in the prostanoid-generating pathway, in the IL-1beta-induced release of SP from DRG cells. Prostaglandins phospholipase A2 group IB Rattus norvegicus
3 These observations suggested that two types of PLA2, sPLA2 -IIA and cPLA2, were involved in the IL-1beta-induced release of SP from DRG cells, and that the functional cross-talk between the two enzymes might help to control their activity in the prostanoid-generating system in DRG cells. Prostaglandins phospholipase A2 group IB Rattus norvegicus