Pub. Date : 2002 Jun 21
PMID : 11953438
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ligand-binding analyses were conducted to examine effects of residue changes in putative catalytic and regulatory isocitrate-binding sites respectively contained in IDH2 and IDH1 subunits. | isocitric acid | isocitrate dehydrogenase (NAD(+)) IDH2 | Saccharomyces cerevisiae S288C |
| 2 | Replacement of homologous serine residues in either subunit site, S98A in IDH2 or S92A in IDH1, was found to reduce by half the total number of holoenzyme isocitrate-binding sites, confirming a correlation between detrimental effects on isocitrate binding and respective kinetic defects in catalysis and allosteric activation by AMP. | isocitric acid | isocitrate dehydrogenase (NAD(+)) IDH2 | Saccharomyces cerevisiae S288C |
| 3 | The putative isocitrate-binding sites of IDH1 and IDH2 contain five identical and four nonidentical residues. | isocitric acid | isocitrate dehydrogenase (NAD(+)) IDH2 | Saccharomyces cerevisiae S288C |