Title : Respiration and mitochondrial membrane potential are not required for apoptosis and anti-apoptotic action of Bcl-2 in HeLa cells.

Pub. Date : 2002 Feb

PMID : 11952418






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1 In the present study it was shown that apoptosis and release of cytochrome c induced by staurosporine or by tumor necrosis factor-alpha in HeLa cells were not affected by inhibitors of respiration (rotenone, myxothiazol, antimycin A) or by uncouplers (CCCP, DNP) that decrease the membrane potential at the inner mitochondrial membrane. Carbonyl Cyanide m-Chlorophenyl Hydrazone cytochrome c, somatic Homo sapiens