Title : Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b(5) in the expression system and the differences in the marker activities.

Pub. Date : 2002 Apr

PMID : 11948533






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Because we previously clarified that azelastine, an antiallergy and antiasthmatic drug, is N-demethylated by CYP1A2, CYP2D6, and CYP3A4 in humans, the reaction was used as a model. azelastine cytochrome P450 family 3 subfamily A member 4 Homo sapiens