Title : Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b(5) in the expression system and the differences in the marker activities.

Pub. Date : 2002 Apr

PMID : 11948533






1 Functional Relationships(s)
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1 As marker activities, ethoxyresorufin O-deethylation and phenacetin O-deethylation for CYP1A2, bufuralol 1"-hydroxylation and debrisoquin 4-hydroxylation for CYP2D6, testosterone 6beta-hydroxylation and midazolam 1"-hydroxylation for CYP3A4 were compared. Phenacetin cytochrome P450 family 1 subfamily A member 2 Homo sapiens