Title : Nitric oxide prevents oxidised LDL-induced p53 accumulation, cytochrome c translocation, and apoptosis in macrophages via guanylate cyclase stimulation.

Pub. Date : 2002 May

PMID : 11947902






2 Functional Relationships(s)
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1 Stabilisation of p53 was prevented by preincubation with the NO-donor GSNO or 8-br-cGMP, thus implying a downmodulatory effect of cGMP on pathways that upregulate the tumor suppressor p53. 8-bromoguanosino-3',5'-cyclic monophosphorothioate tumor protein p53 Homo sapiens
2 Stabilisation of p53 was prevented by preincubation with the NO-donor GSNO or 8-br-cGMP, thus implying a downmodulatory effect of cGMP on pathways that upregulate the tumor suppressor p53. 8-bromoguanosino-3',5'-cyclic monophosphorothioate tumor protein p53 Homo sapiens