Pub. Date : 2002 Jun 14
PMID : 11943772
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling. | Proline | FYN proto-oncogene, Src family tyrosine kinase | Homo sapiens |
| 2 | Molecular cloning of GPVI has revealed the presence of a proline-rich domain in the sequence of GPVI cytoplasmic tail which has the consensus for interaction with the Src homology 3 (SH3) domains of Fyn and Lyn. | Proline | FYN proto-oncogene, Src family tyrosine kinase | Homo sapiens |
| 3 | Furthermore, depletion of the proline-rich domain in GPVI (Pro(-)-GPVI) prevented binding of Fyn and Lyn and markedly reduced phosphorylation of FcR gamma-chain in transiently transfected COS-7 cells, but did not affect the association of the gamma-chain with GPVI. | Proline | FYN proto-oncogene, Src family tyrosine kinase | Homo sapiens |
| 4 | These findings demonstrate that the proline-rich domain of GPVI mediates the association with Fyn/Lyn via their SH3 domain and that this interaction initiates activation signals through GPVI. | Proline | FYN proto-oncogene, Src family tyrosine kinase | Homo sapiens |