Title : Effect of the iron chelator desferrioxamine on manganese-induced toxicity of rat pheochromocytoma (PC12) cells.

Pub. Date : 2002 Apr 1

PMID : 11933051






1 Functional Relationships(s)
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1 DfO also stimulated Mn-induced neuronal differentiation by enhancing the phosphorylation of both ERK1 and 2 and also attenuated the increase in caspase 3-like activity induced by 0.3 mM Mn by approximately 50%, indicating that caspase activation, as reported previously, does not contribute to Mn-induced PC12 cell death. Deferoxamine mitogen activated protein kinase 3 Rattus norvegicus