Pub. Date : 2002 Jun 7
PMID : 11929863
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of matrix metalloproteinase-2 by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species. | Reactive Oxygen Species | superoxide dismutase 2 | Homo sapiens |
| 2 | We hypothesized that manganese superoxide dismutase (MnSOD) could mediate MMP-2 activity by changing the intracellular ROS level and that nitric oxide ((. | Reactive Oxygen Species | superoxide dismutase 2 | Homo sapiens |
| 3 | We hypothesized that manganese superoxide dismutase (MnSOD) could mediate MMP-2 activity by changing the intracellular ROS level and that nitric oxide ((. | Reactive Oxygen Species | superoxide dismutase 2 | Homo sapiens |
| 4 | Our data demonstrated that overexpression of MnSOD stimulated the activation of MMP-2 with a corresponding elevation of ROS. | Reactive Oxygen Species | superoxide dismutase 2 | Homo sapiens |
| 5 | A decrease in ROS by ebselen, a glutathione peroxidase mimetic, or by transduction of adenovirus containing human catalase or glutathione peroxidase cDNA abolished the effect of MnSOD on MMP-2 activation. | Reactive Oxygen Species | superoxide dismutase 2 | Homo sapiens |
| 6 | These results indicate that MnSOD induces MMP-2 activity by regulation of intracellular ROS and imply that signaling pathways involving (. | Reactive Oxygen Species | superoxide dismutase 2 | Homo sapiens |