Title : Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways.

Pub. Date : 2002 Apr 15

PMID : 11929748






2 Functional Relationships(s)
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Protein Name
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1 Initially described in a patient with all-trans retinoic acid (ATRA)-unresponsive disease, STAT5b-RARalpha resulted from an interstitial deletion on chromosome 17. Tretinoin signal transducer and activator of transcription 5B Homo sapiens
2 STAT5b-RARalpha bound to retinoic acid response elements (RAREs) both as a homodimer and as a heterodimer with RXRalpha and inhibited wild-type RARalpha/RXRalpha transactivation. Tretinoin signal transducer and activator of transcription 5B Homo sapiens