Pub. Date : 2002 Apr
PMID : 11916938
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Flux through the hexosamine pathway is a determinant of nuclear factor kappaB- dependent promoter activation. | Hexosamines | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Overexpression of glutamine:fructose-6-phosphate amidotransferase (GFAT), the rate-limiting enzyme for flux through the hexosamine pathway, led to a 2.2-fold increase in NF-kappaB enhancer activity; the combination of GFAT overexpression and high glucose increased activity 2.8-fold, and these increases were prevented by 40 micromol/l O-diazoacetyl-L-serine (azaserine) or 6-diazo-5-oxonorleucine. | Hexosamines | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | These results suggest that increased flux through the hexosamine pathway leads to NF-kappaB-dependent promoter activation in MCs. | Hexosamines | nuclear factor kappa B subunit 1 | Homo sapiens |