Pub. Date : 2002 Apr
PMID : 11916938
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In MCs, RT-PCR revealed that high glucose (30 mmol/l) and glucosamine (1 mmol/l) increased mRNA levels for vascular cell adhesion molecule 1 (VCAM-1) and increased the activity of an NF-kappaB enhancer by 1.5- and 2-fold, respectively. | Glucose | vascular cell adhesion molecule 1 | Homo sapiens |
| 2 | In MCs, RT-PCR revealed that high glucose (30 mmol/l) and glucosamine (1 mmol/l) increased mRNA levels for vascular cell adhesion molecule 1 (VCAM-1) and increased the activity of an NF-kappaB enhancer by 1.5- and 2-fold, respectively. | Glucose | vascular cell adhesion molecule 1 | Homo sapiens |
| 3 | Both glucose and glucosamine dose-dependently increased human VCAM-1 promoter activity. | Glucose | vascular cell adhesion molecule 1 | Homo sapiens |
| 4 | In addition, GFAT overexpression activated the VCAM-1 promoter (2.25-fold), with further augmentation by high glucose and abrogation by inhibitors of GFAT, NF-kappaB, and O-glycosylation. | Glucose | vascular cell adhesion molecule 1 | Homo sapiens |
| 5 | Inactivation of the two NF-kappaB sites in the VCAM-1 promoter abolished its response to high glucose, glucosamine, and GFAT overexpression. | Glucose | vascular cell adhesion molecule 1 | Homo sapiens |