Pub. Date : 2002 Jan
PMID : 11916128
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-gamma and IL-4 in human keratinocytes. | Histamine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | We therefore examined the capacity of histamine to modulate the production of interleukin (IL)-6 and IL-8 by keratinocytes. | Histamine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | We found that histamine significantly augmented the production of IL-6 and IL-8 in a dose- and time-dependent manner. | Histamine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | The histamine-induced up-regulation of IL-6 and IL-8 production, however, was completely abrogated by a combination of pyrilamine and cimetidine. | Histamine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | On the other hand, the production of IL-8 was inhibited by IFN-gamma, and IFN-gamma and IL-4 both completely abrogated the histamine-induced IL-8 production. | Histamine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 6 | On the other hand, the production of IL-8 was inhibited by IFN-gamma, and IFN-gamma and IL-4 both completely abrogated the histamine-induced IL-8 production. | Histamine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 7 | These results suggest that the histamine-induced IL-6 production and IL-8 production are differentially regulated by IFN-gamma and IL-4. | Histamine | C-X-C motif chemokine ligand 8 | Homo sapiens |