Pub. Date : 2002 Mar
PMID : 11914744
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CONCLUSION/INTERPRETATION: IFN gamma and TNFalpha synergistically induced MHC class II expression on insulinoma cells through the induction of CIITA; nicotinamide reduced the expression of cytokine-induced MHC class II expression on insulinoma cells through its effect on CIITA expression; and the preventive effect of nicotimamide on Type I (insulin-dependent) diabetes mellitus is probably due to its effect of MHC class II expression rather than that on islet cell apoptosis. | Niacinamide | tumor necrosis factor | Homo sapiens |