Pub. Date : 2002 Feb 20
PMID : 11911885
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Dbl homology (DH) domain was first identified in the Dbl oncogene product as the limit region required for mediating guanine nucleotide exchange on the Rho family GTPase Cdc42. | Guanine Nucleotides | MCF.2 cell line derived transforming sequence | Homo sapiens |
| 2 | The Dbl homology (DH) domain was first identified in the Dbl oncogene product as the limit region required for mediating guanine nucleotide exchange on the Rho family GTPase Cdc42. | Guanine Nucleotides | MCF.2 cell line derived transforming sequence | Homo sapiens |
| 3 | In each case, a pleckstrin homology (PH) domain immediately follows the DH domain and this tandem DH-PH module is the signature motif of the Dbl family of guanine nucleotide exchange factors (GEFs). | Guanine Nucleotides | MCF.2 cell line derived transforming sequence | Homo sapiens |
| 4 | Recent structural studies have provided significant insight into the molecular basis of guanine nucleotide exchange by Dbl family GEFs, opening the door for understanding the specificity of the DH/GTPase interaction as well as providing a starting point for understanding how the exchange activity of these proteins is modulated to achieve specific biological outcomes in the cell. | Guanine Nucleotides | MCF.2 cell line derived transforming sequence | Homo sapiens |