Title : Ethanol stimulates cAMP-responsive element (CRE)-mediated transcription via CRE-binding protein and cAMP-dependent protein kinase.

Pub. Date : 2002 Apr

PMID : 11907158






2 Functional Relationships(s)
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1 We have shown in the NG108-15 neuroblastoma x glioma hybrid cell line that ethanol increases cellular cAMP levels via activation of adenosine A(2) receptors, leading to phosphorylation of the cAMP response element-binding protein (CREB). Cyclic AMP cAMP responsive element binding protein 1 Mus musculus
2 Our data suggest that ethanol induces cAMP-dependent gene expression regulated by CREB and PKA and that this signaling pathway may mediate some of the addictive behaviors underlying alcoholism. Cyclic AMP cAMP responsive element binding protein 1 Mus musculus