Title : Adaptative response of antioxidant enzymes in different areas of rat brain after repeated d-amphetamine administration.

Pub. Date : 2001 Jul

PMID : 11900599






2 Functional Relationships(s)
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1 In this study, the activities of several antioxidant enzymes in different areas of rat brain were measured after repeated administration of d-amphetamine sulphate (sc, 20 mg/kg/day, for 14 days), namely glutathione-S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GRed), catalase, and superoxide dismutase (SOD). Dextroamphetamine catalase Rattus norvegicus
2 When compared to a pair-fed control group, d-amphetamine treatment enhanced the activity of GST in hypothalamus to 167%, GPx in striatum to 127%, in nucleus accumbens to 192%, and in medial prefrontal cortex to 139%, GRed in hypothalamus to 139%, as well as catalase in medial prefrontal cortex to 153%. Dextroamphetamine catalase Rattus norvegicus