Title : Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms.

Pub. Date : 2002 Apr

PMID : 11894120






2 Functional Relationships(s)
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Protein Name
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1 In LS174T cells, the antisense oligonucleotide, but not the mismatch oligonucleotide, specifically inhibited MDM2 expression, resulting in a significant increase in irinotecan-associated p53 activation and p21 induction. Oligonucleotides H3 histone pseudogene 16 Homo sapiens
2 In DLD-1 cells, the antisense oligonucleotide specifically inhibited MDM2 expression, resulting in a significant increase in irinotecan-associated p21 induction although mutant p53 levels remained unchanged. Oligonucleotides H3 histone pseudogene 16 Homo sapiens