Title : Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes.

Pub. Date : 2002 Apr

PMID : 11893554






5 Functional Relationships(s)
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1 Pretreatment with the ADH inhibitor 4-methylpyrazole (4-MP) or the aldehyde dehydrogenase inhibitor cyanamide prevented or augmented the ethanol-induced inhibition, respectively, in the ADH but not the FVB group. Fomepizole aldo-keto reductase family 1, member A1 (aldehyde reductase) Mus musculus
2 Pretreatment with the ADH inhibitor 4-methylpyrazole (4-MP) or the aldehyde dehydrogenase inhibitor cyanamide prevented or augmented the ethanol-induced inhibition, respectively, in the ADH but not the FVB group. Fomepizole aldo-keto reductase family 1, member A1 (aldehyde reductase) Mus musculus
3 Pretreatment with the ADH inhibitor 4-methylpyrazole (4-MP) or the aldehyde dehydrogenase inhibitor cyanamide prevented or augmented the ethanol-induced inhibition, respectively, in the ADH but not the FVB group. Fomepizole aldo-keto reductase family 1, member A1 (aldehyde reductase) Mus musculus
4 Pretreatment with the ADH inhibitor 4-methylpyrazole (4-MP) or the aldehyde dehydrogenase inhibitor cyanamide prevented or augmented the ethanol-induced inhibition, respectively, in the ADH but not the FVB group. Fomepizole aldo-keto reductase family 1, member A1 (aldehyde reductase) Mus musculus
5 The ADH transgene also substantiated the ethanol-induced inhibition of maximal velocity of shortening/relengthening and unmasked an ethanol-induced prolongation of the duration of shortening/relengthening, which was abolished by 4-MP. Fomepizole aldo-keto reductase family 1, member A1 (aldehyde reductase) Mus musculus