Pub. Date : 2002 Mar
PMID : 11893129
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To better understand the interaction between genotype and response to warfarin therapy, we determined the frequency and functional effects of polymorphisms of the predominant cytochrome P450 subfamily responsible for warfarin metabolism (eg, CYP2C9) in an ethnically defined U.S. patient population. | Warfarin | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | To better understand the interaction between genotype and response to warfarin therapy, we determined the frequency and functional effects of polymorphisms of the predominant cytochrome P450 subfamily responsible for warfarin metabolism (eg, CYP2C9) in an ethnically defined U.S. patient population. | Warfarin | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 3 | Patients with CYP polymorphisms (2C9*2, 2C9*3) had significantly lower warfarin doses compared to patients with wild-type genotypes [30.6 (+/- 2.5) mg versus 40.1 (+/- 1.7) mg, p = 0.0021] . | Warfarin | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 4 | Stepwise backward regression analysis suggested a moderate ability to predict warfarin dose based on CYP genotype (r2 = 0.26), p < 0.01). | Warfarin | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 5 | As interactions between genetic factors and other variables that influence warfarin effect are more completely understood, CYP analysis may prove a useful adjunct for increasing the safety and efficacy of this agent. | Warfarin | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |