Title : Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands.

Pub. Date : 2002

PMID : 11891851






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 CAR and PXR have a rather broad, overlapping set of ligands that range from natural steroids to xenobiotics and also recognize similar DNA binding sites, referred to as response elements (REs), primarily in promoter regions of cytochrome P450 (CYP) genes. Steroids nuclear receptor subfamily 1 group I member 2 Homo sapiens
2 Since an iNOS-induced production of NO is known to influence inflammation and apoptosis, a CAR- and PXR-regulated iNOS activity may explain a modulatory effect of steroids and xenobiotics on these cellular processes. Steroids nuclear receptor subfamily 1 group I member 2 Homo sapiens