Title : Genotoxic and recombinogenic activities of the two beta-carboline alkaloids harman and harmine in Saccharomyces cerevisiae.

Pub. Date : 2002 Mar 20

PMID : 11890933






1 Functional Relationships(s)
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1 Mutants defective in excision-resynthesis repair (rad3 and rad1), in error-prone repair (rad6) and in recombinational repair (rad52) showed enhanced sensitivity to harmine and harman, but the ranking of sensitivities was different for the two alkaloids. Harmine ssDNA endodeoxyribonuclease RAD1 Saccharomyces cerevisiae S288C