Pub. Date : 2002 Feb 22
PMID : 11890899
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FK506 (Tacrolimus) and cyclosporin A exert their immunosuppressive effects via a common mechanism, calcineurin inhibition, after binding to intracellular proteins termed immunophilins: FK506-binding protein (FKBP) and cyclophilin. | Tacrolimus | FK506 binding protein 1a | Mus musculus |
| 2 | FK506 (Tacrolimus) and cyclosporin A exert their immunosuppressive effects via a common mechanism, calcineurin inhibition, after binding to intracellular proteins termed immunophilins: FK506-binding protein (FKBP) and cyclophilin. | Tacrolimus | FK506 binding protein 1a | Mus musculus |
| 3 | FK506 (Tacrolimus) and cyclosporin A exert their immunosuppressive effects via a common mechanism, calcineurin inhibition, after binding to intracellular proteins termed immunophilins: FK506-binding protein (FKBP) and cyclophilin. | Tacrolimus | FK506 binding protein 1a | Mus musculus |
| 4 | FK506 (Tacrolimus) and cyclosporin A exert their immunosuppressive effects via a common mechanism, calcineurin inhibition, after binding to intracellular proteins termed immunophilins: FK506-binding protein (FKBP) and cyclophilin. | Tacrolimus | FK506 binding protein 1a | Mus musculus |
| 5 | Rapamycin, an immunosuppressant that binds to FKBP, antagonized the effect of FK506. | Tacrolimus | FK506 binding protein 1a | Mus musculus |
| 6 | Taken together, these results suggest that FK506 induces chondrogenic differentiation of ATDC5 cells via a calcineurin-independent mechanism, after binding to FKBP. | Tacrolimus | FK506 binding protein 1a | Mus musculus |