Pub. Date : 2001 Dec 21
PMID : 11884025
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The study was designed to investigate whether colitis induced by trinitrobenzene sulphonic acid (TNBS) in rats produces an increase in TACE activity and/or expression and whether its pharmacological inhibition reduces TNF-alpha levels, iNOS expression and colonic damage in this model. | Trinitrobenzenesulfonic Acid | tumor necrosis factor | Rattus norvegicus |
2 | Instillation of TNBS caused an increase in TACE activity and expression and the release of TNF-alpha. | Trinitrobenzenesulfonic Acid | tumor necrosis factor | Rattus norvegicus |
3 | BB1101 blocked TNBS-induced increase in TACE activity, TNF-alpha release and iNOS expression. | Trinitrobenzenesulfonic Acid | tumor necrosis factor | Rattus norvegicus |
4 | TNBS causes TNF-alpha release by an increase in TACE activity and expression and this results in the expression of iNOS and subsequent inflammation, suggesting that TACE inhibition may prove useful as a therapeutic means in IBD. | Trinitrobenzenesulfonic Acid | tumor necrosis factor | Rattus norvegicus |