Title : Implication of TNF-alpha convertase (TACE/ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis.

Pub. Date : 2001 Dec 21

PMID : 11884025






4 Functional Relationships(s)
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1 The study was designed to investigate whether colitis induced by trinitrobenzene sulphonic acid (TNBS) in rats produces an increase in TACE activity and/or expression and whether its pharmacological inhibition reduces TNF-alpha levels, iNOS expression and colonic damage in this model. Trinitrobenzenesulfonic Acid tumor necrosis factor Rattus norvegicus
2 Instillation of TNBS caused an increase in TACE activity and expression and the release of TNF-alpha. Trinitrobenzenesulfonic Acid tumor necrosis factor Rattus norvegicus
3 BB1101 blocked TNBS-induced increase in TACE activity, TNF-alpha release and iNOS expression. Trinitrobenzenesulfonic Acid tumor necrosis factor Rattus norvegicus
4 TNBS causes TNF-alpha release by an increase in TACE activity and expression and this results in the expression of iNOS and subsequent inflammation, suggesting that TACE inhibition may prove useful as a therapeutic means in IBD. Trinitrobenzenesulfonic Acid tumor necrosis factor Rattus norvegicus