Pub. Date : 2002 Feb
PMID : 11882577
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-1beta (IL-1beta), a proinflammatory cytokine, induces cyclooxygenase-2 (COX-2) in cultured neonatal ventricular myocytes (NVMs), resulting in the preferential production of prostaglandin E(2) (PGE(2)). | Prostaglandins E | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | We concluded that (1) PGE(2) production requires the induction of its specific synthase; (2) in myocytes, the inducible enzymes COX-2 and PGES are perinuclear; and (3) PGE(2) and sulprostone induce cardiac myocyte growth but seem to activate a different subset of EP receptors. | Prostaglandins E | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |