Title : Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.

Pub. Date : 2002 Mar 1

PMID : 11880504






2 Functional Relationships(s)
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Protein Name
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1 When maintained on a folic acid-deficient diet, amyloid precursor protein (APP) mutant transgenic mice, but not wild-type mice, exhibited increased cellular DNA damage and hippocampal neurodegeneration. Folic Acid amyloid beta (A4) precursor protein Mus musculus
2 Our data suggest that folic acid deficiency and homocysteine impair DNA repair in neurons, which sensitizes them to oxidative damage induced by Abeta. Folic Acid amyloid beta (A4) precursor protein Mus musculus