Title : Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1.

Pub. Date : 2002 Feb

PMID : 11872643






1 Functional Relationships(s)
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1 Significant increase of hydroxyl radical levels by day 4 of PB exposure accompanied the accumulation of 8-OHdG in the nucleus and P-450 isoenzymes CYP2B1/2 and CYP3A2 in the cytoplasm of hepatocytes. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus