Title : A double cysteine trkA mutant exhibiting reduced NGF binding and delayed Erk signaling.

Pub. Date : 2001 Dec

PMID : 11859925






2 Functional Relationships(s)
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1 However, basic fibroblast growth factor (bFGF) induced rapid phosphorylation of Erk1/2, and [3H]thymidine incorporation in NIH3T3, WT11, single mutant (SM), and double mutant (DM) cells, suggesting that the impaired NGF-induced Erk phosphorylation and thymidine incorporation observed in DM cells are due to the double-cysteine mutations in the trkA receptor. Thymidine fibroblast growth factor 2 Homo sapiens
2 However, basic fibroblast growth factor (bFGF) induced rapid phosphorylation of Erk1/2, and [3H]thymidine incorporation in NIH3T3, WT11, single mutant (SM), and double mutant (DM) cells, suggesting that the impaired NGF-induced Erk phosphorylation and thymidine incorporation observed in DM cells are due to the double-cysteine mutations in the trkA receptor. Thymidine fibroblast growth factor 2 Homo sapiens