Pub. Date : 2002 Mar 1
PMID : 11855844
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts. | Diphosphonates | TNF receptor superfamily member 11b | Homo sapiens |
| 2 | In this study, we assessed the effects of the bisphosphonates pamidronate (PAM) and zoledronic acid (ZOL) on OPG mRNA steady-state levels (by semiquantitative RT-PCR) and protein production (by ELISA) in primary human osteoblasts (hOB). | Diphosphonates | TNF receptor superfamily member 11b | Homo sapiens |
| 3 | In conclusion, our data suggest that bisphosphonates modulate OPG production by normal human osteoblasts, which may contribute to the inhibition of osteoclastic bone resorption. | Diphosphonates | TNF receptor superfamily member 11b | Homo sapiens |
| 4 | Since, OPG production increases with osteoblastic cell maturation, enhancement of OPG by bisphosphonates could be related to their stimulatory effects on osteoblastic differentiation. | Diphosphonates | TNF receptor superfamily member 11b | Homo sapiens |
| 5 | Since, OPG production increases with osteoblastic cell maturation, enhancement of OPG by bisphosphonates could be related to their stimulatory effects on osteoblastic differentiation. | Diphosphonates | TNF receptor superfamily member 11b | Homo sapiens |