Title : Increased tissue inhibitor of metalloproteinase-1 expression and inhibition of gelatinase A activity in buccal mucosal fibroblasts by arecoline as possible mechanisms for oral submucous fibrosis.

Pub. Date : 2002 Feb

PMID : 11854068






3 Functional Relationships(s)
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1 To verify whether arecoline, a major areca nut alkaloid, could affect TIMP or MMP production by human BMFs, Western blots and gelatine zymography were used. Arecoline matrix metallopeptidase 2 Homo sapiens
2 In addition, arecoline was found to inhibit MMP-2 secretion and production at the concentration level of 40 microg/ml. Arecoline matrix metallopeptidase 2 Homo sapiens
3 Taken together, it was found that arecoline acted not only as an inhibitor on gelatinolytic activity of MMP-2, but also a stimulator for TIMP-1 activity. Arecoline matrix metallopeptidase 2 Homo sapiens