Pub. Date : 2002 Apr 26
PMID : 11842094
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A member of the N-terminal nucleophile class of amidotransferases, GFAT transfers the amino group from the L-glutamine amide to D-fructose 6-phosphate, producing glutamic acid and glucosamine 6-phosphate. | fructose-6-phosphate | glutamine--fructose-6-phosphate transaminase 1 | Homo sapiens |
| 2 | The kinetic constants reported previously for mammalian GFAT implicate a relatively low affinity for the acceptor substrate, fructose 6-phosphate (Fru-6-P, K(m) 0.2-1 mm). | fructose-6-phosphate | glutamine--fructose-6-phosphate transaminase 1 | Homo sapiens |
| 3 | The kinetic constants reported previously for mammalian GFAT implicate a relatively low affinity for the acceptor substrate, fructose 6-phosphate (Fru-6-P, K(m) 0.2-1 mm). | fructose-6-phosphate | glutamine--fructose-6-phosphate transaminase 1 | Homo sapiens |
| 4 | In a second assay method that measures the stimulation of glutaminase activity, a K(d) of 2 microm was measured for Fru-6-P binding to hGFAT1. | fructose-6-phosphate | glutamine--fructose-6-phosphate transaminase 1 | Homo sapiens |
| 5 | These data suggest that hGFAT1 is fully active at physiological levels of Fru-6-P and may be regulated by its product GlcN-6-P in addition to the pathway end product, UDP-GlcNAc. | fructose-6-phosphate | glutamine--fructose-6-phosphate transaminase 1 | Homo sapiens |