Title : The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria.

Pub. Date : 2002 Apr 19

PMID : 11842081






1 Functional Relationships(s)
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1 In respect to downstream effectors of PI3K, we found that expression of active Akt, but not serum and glucocorticoid-induced protein kinase (SGK), suppressed staurosporine-induced translocation of Bax, whereas dominant negative Akt moderately promoted Bax translocation. Staurosporine AKT serine/threonine kinase 1 Homo sapiens