Title : Animal model for angiotensin II effects in the internal anal sphincter smooth muscle: mechanism of action.

Pub. Date : 2002 Mar

PMID : 11841996






2 Functional Relationships(s)
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1 ANG II-induced contraction of rat IAS smooth muscle and SMC was attenuated by tyrosine kinase inhibitors genistein and tyrphostin, protein kinase C (PKC) inhibitor H-7, Ca(2+) channel blocker nicardipine, Rho kinase inhibitor Y-27632 or p(44/42) mitogen-activating protein kinase (MAPK(44/42)) inhibitor PD-98059. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine angiotensinogen Rattus norvegicus
2 Combinations of nicardipine and H-7, Y-27632, and PD-98059 caused further attenuation of the ANG II effects. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine angiotensinogen Rattus norvegicus