Title : Differential regulation of multidrug resistance-associated protein 2 (MRP2) and cytochromes P450 2B1/2 and 3A1/2 in phenobarbital-treated hepatocytes.

Pub. Date : 2002 Jan 15

PMID : 11841808






2 Functional Relationships(s)
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1 In the present study, we have investigated its expression in response to phenobarbital, a liver tumor promoter known to up-regulate hepatic cytochromes P450 (CYPs), such as CYP2B1/2 and CYP3A1/2. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus
2 In addition, hepatic MRP2 expression remained unaltered in rats treated by phenobarbital that, by contrast, increased CYP2B1/2 and CYP3A1/2 gene expression in the liver. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus