Title : Control of renin secretion in the dog. Effects of furosemide on the vascular and macula densa receptors.

Pub. Date : 1975 Oct

PMID : 1182938






5 Functional Relationships(s)
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1 Experiments were undertaken to investigate further the effect of furosemide on renin secretion in the anesthetized dog. Furosemide renin Canis lupus familiaris
2 Furosemide, in a dose of 5 mg/kg, increased renin secretion and decreased renal resistance in dogs with a nonfiltering kidney. Furosemide renin Canis lupus familiaris
3 However, following dilation of the intact filtering kidney with acetylcholine, furosemide caused an increase in renin secretion. Furosemide renin Canis lupus familiaris
4 Following propranolol treatment, furosemide increased renin secretion in the filtering kidney but had no effect on renal resistance. Furosemide renin Canis lupus familiaris
5 These experiments indicate that furosemide stimulates renin secretion by both the macula densa and the baroreceptor mechanisms. Furosemide renin Canis lupus familiaris