Title : Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells.

Pub. Date : 2002 Feb 8

PMID : 11820781






1 Functional Relationships(s)
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1 These results, collectively, suggest a ROS-related, COX-2-independent mechanism for the induction of drug resistance gene expression that bears important implications to the roles of NSAIDs in colorectal carcinogenesis and inflammatory response. Reactive Oxygen Species mitochondrially encoded cytochrome c oxidase II Homo sapiens