Title : Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase.

Pub. Date : 2002 Feb

PMID : 11809847






2 Functional Relationships(s)
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1 Under the same experimental conditions, the anti-herpetic (E)-5-(2-bromovinyl)-2"-deoxyuridine (BVDU) derivative was efficiently converted to BVDU-MP and BVDU-DP by both VZV TK and HSV-1 TK and further, into BVDU-TP, by NDP kinase. brivudine cytidine/uridine monophosphate kinase 2 Homo sapiens
2 Under the same experimental conditions, the anti-herpetic (E)-5-(2-bromovinyl)-2"-deoxyuridine (BVDU) derivative was efficiently converted to BVDU-MP and BVDU-DP by both VZV TK and HSV-1 TK and further, into BVDU-TP, by NDP kinase. brivudine cytidine/uridine monophosphate kinase 2 Homo sapiens