Title : Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference.

Pub. Date : 2002 Jan 15

PMID : 11809726






1 Functional Relationships(s)
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1 In mammalian cells we tested sequence-specific small dsRNAs of 22 nt; these rescued the toxicity and caspase-3 activation induced by plasmids expressing a transcript encoding an expanded polyglutamine tract. polyglutamine caspase 3 Homo sapiens