Pub. Date : 2002 Jan-Feb
PMID : 11807932
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The potency of PAH mixtures often is calculated using relative potency values (BAP equivalency factors). | Benzo(a)pyrene | phenylalanine hydroxylase | Homo sapiens |
| 2 | Moreover, when the PAH composition of the mixture has been analysed, prediction of the potency of PAH mixtures by BAP equivalency factors could be compared with the observed PAH potency. | Benzo(a)pyrene | phenylalanine hydroxylase | Homo sapiens |
| 3 | Moreover, when the PAH composition of the mixture has been analysed, prediction of the potency of PAH mixtures by BAP equivalency factors could be compared with the observed PAH potency. | Benzo(a)pyrene | phenylalanine hydroxylase | Homo sapiens |
| 4 | Moreover, when the PAH composition of the mixture has been analysed, prediction of the potency of PAH mixtures by BAP equivalency factors could be compared with the observed PAH potency. | Benzo(a)pyrene | phenylalanine hydroxylase | Homo sapiens |
| 5 | Evaluation of several studies with various PAH mixtures revealed that the potency ratio between pure BAP and the PAH mixture in the same assay is highly dependent on the exposure pathway and the target organ, therefore potency estimates for PAH mixtures should be derived separately for oral, dermal and inhalative exposure using data from studies with the relevant pathway. | Benzo(a)pyrene | phenylalanine hydroxylase | Homo sapiens |
| 6 | Evaluation of several studies with various PAH mixtures revealed that the potency ratio between pure BAP and the PAH mixture in the same assay is highly dependent on the exposure pathway and the target organ, therefore potency estimates for PAH mixtures should be derived separately for oral, dermal and inhalative exposure using data from studies with the relevant pathway. | Benzo(a)pyrene | phenylalanine hydroxylase | Homo sapiens |
| 7 | Evaluation of several studies with various PAH mixtures revealed that the potency ratio between pure BAP and the PAH mixture in the same assay is highly dependent on the exposure pathway and the target organ, therefore potency estimates for PAH mixtures should be derived separately for oral, dermal and inhalative exposure using data from studies with the relevant pathway. | Benzo(a)pyrene | phenylalanine hydroxylase | Homo sapiens |
| 8 | By using incidence data for all exposure-related tumours, a slope factor for humans of 11.5 (human excess risk per oral lifetime exposure with 1 mg BAP kg(-1)day(-1) in a PAH mixture) was obtained. | Benzo(a)pyrene | phenylalanine hydroxylase | Homo sapiens |
| 9 | Our analysis led to the conclusion that the contribution of BAP to the carcinogenic potency of the mixture depends on the exposure pathway and type of cancer observed but is relatively constant for various PAH mixtures from industrial sources. | Benzo(a)pyrene | phenylalanine hydroxylase | Homo sapiens |