Title : Lack of CYP3A4 inhibition by grapefruit juice and ketoconazole upon clozapine administration in vivo.

Pub. Date : 2001

PMID : 11791889






1 Functional Relationships(s)
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1 These results indicate that CYP 3A4 inhibition may not be clinically significant compared to CYP 1A2, as previous studies show a dramatic increase in CLZ plasma concentrations with fluvoxamine (CYP 1A2 inhibitor). Fluvoxamine cytochrome P450 family 1 subfamily A member 2 Homo sapiens