Title : Glucose uptake and insulin action in human adipose tissue--influence of BMI, anatomical depot and body fat distribution.

Pub. Date : 2002 Jan

PMID : 11791142






7 Functional Relationships(s)
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1 DESIGN: In vitro study of basal and insulin-stimulated 2-deoxyglucose uptake in human omental and subcutaneous adipose tissue explants derived from patients undergoing elective abdominal surgery. Deoxyglucose insulin Homo sapiens
2 MEASUREMENTS: Fatness and fat distribution parameters (by anthropometry), basal and insulin stimulated [(3)H]-2-deoxyglucose uptake in omental and subcutaneous adipose tissue explants. Deoxyglucose insulin Homo sapiens
3 RESULTS: In adipose tissue from lean subjects transport of 2-deoxyglucose over basal was stimulated approximately two-fold by insulin. Deoxyglucose insulin Homo sapiens
4 Following incubation with 100-nM insulin for 35 min, insulin-stimulated 2-deoxyglucose transport was significantly lower in both omental and subcutaneous adipose tissue of obese and overweight compared to lean subjects. Deoxyglucose insulin Homo sapiens
5 Following incubation with 100-nM insulin for 35 min, insulin-stimulated 2-deoxyglucose transport was significantly lower in both omental and subcutaneous adipose tissue of obese and overweight compared to lean subjects. Deoxyglucose insulin Homo sapiens
6 The reduction in insulin-stimulated 2-deoxyglucose uptake seen in overweight and obese subjects was relatively similar in both depots. Deoxyglucose insulin Homo sapiens
7 However, insulin responsive 2-deoxyglucose transport was significantly lower in the omental adipose tissue of subjects with central obesity, as compared to that of subjects with peripheral obesity. Deoxyglucose insulin Homo sapiens